ea0031p192 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2013
Patterson Michael
, Tadross John
, Suzuki Keisuke
, Beale Kylie
, Boughton Charoltte
, Ghatei Mohammad
, Bloom Stephen
Augurin is a putative neuropeptide product of the esophageal cancer-related gene-4. We have previously demonstrated intra-cerebroventricular (ICV) and intra-paraventricular nucleus (iPVN) administration of augurin (71148) stimulates the hypothalamo-pituitary-adrenal axis in male Wistar rats. This effect was dependent on the release of CRH. Since CRH is known to inhibit feeding, we hypothesised augurin (71148) would have similar actions. We therefore investigated th...